Mouse Otlx2 / RIEG Expression in the Odontogenic Epithelium Precedes Tooth Initiation and Requires Mesenchyme-Derived Signals for Its Maintenance
Identifieur interne : 000416 ( France/Analysis ); précédent : 000415; suivant : 000417Mouse Otlx2 / RIEG Expression in the Odontogenic Epithelium Precedes Tooth Initiation and Requires Mesenchyme-Derived Signals for Its Maintenance
Auteurs : Marie-Laurence Mucchielli [France] ; Thimios A. Mitsiadis [France] ; Sylva Raffo [France] ; Jean-François Brunet [France] ; Jean-Pierre Proust [France] ; Christo Goridis [France]Source :
- Developmental Biology [ 0012-1606 ] ; 1997.
Descripteurs français
- Wicri :
- topic : Droit d'auteur.
English descriptors
- KwdEn :
- Academic press, Ameloblast, Anlage, Barx1, Barx1 expression, Biol, Branchial, Copyright, Dental epithelium, Dental lamina, Dental mesenchyme, Dental papilla, Ectoderm, Ectomesenchyme, Embryo, Enamel, Enamel epithelium, Enamel knot, Epithelial, Epithelial cells, Epithelial components, Epithelium, Explants, Homeobox, Homeobox gene, Homeobox genes, Hybridization, Incisor, Inner enamel epithelium, Intermedium, Kollar, Labial, Lamina, Lumsden, Mandibular, Mesenchymal, Mesenchyme, Mitsiadis, Molar, Molar mesenchyme, Morphogenesis, Mouse embryos, Msx1, Mucchielli, Nonodontogenic, Odontogenesis, Odontogenic, Oral epithelium, Other ectoderm, Otlx2, Otlx2 expression, Otlx2 transcripts, Outer enamel epithelium, Papilla, Primordium, Recombined, Reticulum, Rieger, Rieger syndrome, Ruch, Second molar, Semina, Stellate, Stellate reticulum, Stomatodeal, Stomatodeal ectoderm, Stratum intermedium, Thesleff, Third molar, Tooth development, Tooth formation, Tooth initiation, Tooth region, Transcription.
- Teeft :
- Academic press, Ameloblast, Anlage, Barx1, Barx1 expression, Biol, Branchial, Copyright, Dental epithelium, Dental lamina, Dental mesenchyme, Dental papilla, Ectoderm, Ectomesenchyme, Embryo, Enamel, Enamel epithelium, Enamel knot, Epithelial, Epithelial cells, Epithelial components, Epithelium, Explants, Homeobox, Homeobox gene, Homeobox genes, Hybridization, Incisor, Inner enamel epithelium, Intermedium, Kollar, Labial, Lamina, Lumsden, Mandibular, Mesenchymal, Mesenchyme, Mitsiadis, Molar, Molar mesenchyme, Morphogenesis, Mouse embryos, Msx1, Mucchielli, Nonodontogenic, Odontogenesis, Odontogenic, Oral epithelium, Other ectoderm, Otlx2, Otlx2 expression, Otlx2 transcripts, Outer enamel epithelium, Papilla, Primordium, Recombined, Reticulum, Rieger, Rieger syndrome, Ruch, Second molar, Semina, Stellate, Stellate reticulum, Stomatodeal, Stomatodeal ectoderm, Stratum intermedium, Thesleff, Third molar, Tooth development, Tooth formation, Tooth initiation, Tooth region, Transcription.
Abstract
Abstract: The mouseOtlx2gene is a new member of thepaired-like family of homeobox genes whose human homologue,RIEG,is involved in Rieger syndrome, an autosomal-dominant disorder. One of the cardinal features of Rieger syndrome is dental hypoplasia, indicating thatOtlx2/RIEGactivity is essential for normal tooth development. Here, we analyzed the expression ofOtlx2during mouse tooth development and studied its regulation in dental explants.Otlx2expression distinguishes stomatodeal from other ectoderm as early as Embryonic Day 8.5, well before tooth initiation. Thereafter, its craniofacial expression becomes restricted to the tooth-forming areas and to the epithelial components of molar and incisor primordia. AlthoughOtlx2induction precedes the specification of odontogenic mesenchyme, tissue recombination experiments show that the maintenance of its expression requires signals from the mesenchyme and that dental mesenchyme has the capacity to induce ectopic expression ofOtlx2in nondental epithelium. Finally, we compareOtlx2expression with that of the recently identified homeodomain transcription factorBarx1expressed in molar mesenchyme. Their strictly complementary expression patterns in the epithelial and mesenchymal components suggest that both genes participate in the reciprocal tissue interactions which are a hallmark of odontogenesis.
Url:
DOI: 10.1006/dbio.1997.8672
Affiliations:
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type="city">Marseille</settlement></placeName><orgName type="university">Université de la Méditerranée</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Developmental Biology</title><title level="j" type="abbrev">YDBIO</title><idno type="ISSN">0012-1606</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">189</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="275">275</biblScope><biblScope unit="page" to="284">284</biblScope></imprint><idno type="ISSN">0012-1606</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0012-1606</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Academic press</term><term>Ameloblast</term><term>Anlage</term><term>Barx1</term><term>Barx1 expression</term><term>Biol</term><term>Branchial</term><term>Copyright</term><term>Dental epithelium</term><term>Dental lamina</term><term>Dental mesenchyme</term><term>Dental papilla</term><term>Ectoderm</term><term>Ectomesenchyme</term><term>Embryo</term><term>Enamel</term><term>Enamel epithelium</term><term>Enamel knot</term><term>Epithelial</term><term>Epithelial cells</term><term>Epithelial components</term><term>Epithelium</term><term>Explants</term><term>Homeobox</term><term>Homeobox gene</term><term>Homeobox genes</term><term>Hybridization</term><term>Incisor</term><term>Inner enamel epithelium</term><term>Intermedium</term><term>Kollar</term><term>Labial</term><term>Lamina</term><term>Lumsden</term><term>Mandibular</term><term>Mesenchymal</term><term>Mesenchyme</term><term>Mitsiadis</term><term>Molar</term><term>Molar mesenchyme</term><term>Morphogenesis</term><term>Mouse embryos</term><term>Msx1</term><term>Mucchielli</term><term>Nonodontogenic</term><term>Odontogenesis</term><term>Odontogenic</term><term>Oral epithelium</term><term>Other ectoderm</term><term>Otlx2</term><term>Otlx2 expression</term><term>Otlx2 transcripts</term><term>Outer enamel epithelium</term><term>Papilla</term><term>Primordium</term><term>Recombined</term><term>Reticulum</term><term>Rieger</term><term>Rieger syndrome</term><term>Ruch</term><term>Second molar</term><term>Semina</term><term>Stellate</term><term>Stellate reticulum</term><term>Stomatodeal</term><term>Stomatodeal ectoderm</term><term>Stratum intermedium</term><term>Thesleff</term><term>Third molar</term><term>Tooth development</term><term>Tooth formation</term><term>Tooth initiation</term><term>Tooth region</term><term>Transcription</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Ameloblast</term><term>Anlage</term><term>Barx1</term><term>Barx1 expression</term><term>Biol</term><term>Branchial</term><term>Copyright</term><term>Dental epithelium</term><term>Dental lamina</term><term>Dental mesenchyme</term><term>Dental papilla</term><term>Ectoderm</term><term>Ectomesenchyme</term><term>Embryo</term><term>Enamel</term><term>Enamel epithelium</term><term>Enamel knot</term><term>Epithelial</term><term>Epithelial cells</term><term>Epithelial components</term><term>Epithelium</term><term>Explants</term><term>Homeobox</term><term>Homeobox gene</term><term>Homeobox genes</term><term>Hybridization</term><term>Incisor</term><term>Inner enamel epithelium</term><term>Intermedium</term><term>Kollar</term><term>Labial</term><term>Lamina</term><term>Lumsden</term><term>Mandibular</term><term>Mesenchymal</term><term>Mesenchyme</term><term>Mitsiadis</term><term>Molar</term><term>Molar mesenchyme</term><term>Morphogenesis</term><term>Mouse embryos</term><term>Msx1</term><term>Mucchielli</term><term>Nonodontogenic</term><term>Odontogenesis</term><term>Odontogenic</term><term>Oral epithelium</term><term>Other ectoderm</term><term>Otlx2</term><term>Otlx2 expression</term><term>Otlx2 transcripts</term><term>Outer enamel epithelium</term><term>Papilla</term><term>Primordium</term><term>Recombined</term><term>Reticulum</term><term>Rieger</term><term>Rieger syndrome</term><term>Ruch</term><term>Second molar</term><term>Semina</term><term>Stellate</term><term>Stellate reticulum</term><term>Stomatodeal</term><term>Stomatodeal ectoderm</term><term>Stratum intermedium</term><term>Thesleff</term><term>Third molar</term><term>Tooth development</term><term>Tooth formation</term><term>Tooth initiation</term><term>Tooth region</term><term>Transcription</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Droit d'auteur</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The mouseOtlx2gene is a new member of thepaired-like family of homeobox genes whose human homologue,RIEG,is involved in Rieger syndrome, an autosomal-dominant disorder. One of the cardinal features of Rieger syndrome is dental hypoplasia, indicating thatOtlx2/RIEGactivity is essential for normal tooth development. Here, we analyzed the expression ofOtlx2during mouse tooth development and studied its regulation in dental explants.Otlx2expression distinguishes stomatodeal from other ectoderm as early as Embryonic Day 8.5, well before tooth initiation. Thereafter, its craniofacial expression becomes restricted to the tooth-forming areas and to the epithelial components of molar and incisor primordia. AlthoughOtlx2induction precedes the specification of odontogenic mesenchyme, tissue recombination experiments show that the maintenance of its expression requires signals from the mesenchyme and that dental mesenchyme has the capacity to induce ectopic expression ofOtlx2in nondental epithelium. Finally, we compareOtlx2expression with that of the recently identified homeodomain transcription factorBarx1expressed in molar mesenchyme. Their strictly complementary expression patterns in the epithelial and mesenchymal components suggest that both genes participate in the reciprocal tissue interactions which are a hallmark of odontogenesis.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement><orgName><li>Université de la Méditerranée</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Mucchielli, Marie Laurence" sort="Mucchielli, Marie Laurence" uniqKey="Mucchielli M" first="Marie-Laurence" last="Mucchielli">Marie-Laurence Mucchielli</name></region><name sortKey="Brunet, Jean Francois" sort="Brunet, Jean Francois" uniqKey="Brunet J" first="Jean-François" last="Brunet">Jean-François Brunet</name><name sortKey="Goridis, Christo" sort="Goridis, Christo" uniqKey="Goridis C" first="Christo" last="Goridis">Christo Goridis</name><name sortKey="Mitsiadis, Thimios A" sort="Mitsiadis, Thimios A" uniqKey="Mitsiadis T" first="Thimios A." last="Mitsiadis">Thimios A. Mitsiadis</name><name sortKey="Proust, Jean Pierre" sort="Proust, Jean Pierre" uniqKey="Proust J" first="Jean-Pierre" last="Proust">Jean-Pierre Proust</name><name sortKey="Raffo, Sylva" sort="Raffo, Sylva" uniqKey="Raffo S" first="Sylva" last="Raffo">Sylva Raffo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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